APC Dendritic Cells play a critical role initiating tumor destruction by activating T Cells. Tumor cells produce antigens that are captured by antigen presenting cells (APCs). The APCs that activate T-Cells are usually dendritic cells because T Cells cannot recognize or respond to free or soluble antigens but they can recognize and respond to antigens that have been processed and presented by APC dendritic cells. Once T cells undergo activation they then proliferate and migrate to the tumor cells to release apoptosis-inducing proteins.