Thrombopoietin (TPO) is the primary stimulator of platelet production. It binds to the extracellular domain of the thrombopoietin receptor on the surface membrane of megakaryocytes in the bone marrow. Disease caused by decreased platelet production can be augmented by platelet-stimulating agents. They activate thrombopoietin receptors by interacting with the transmembrane domains, complementing native TPO and boosting platelet production.
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